chalkboard diagram of prefrontal cortex region

The Role of the Prefrontal Cortex in our Cognitive Function

The prefrontal cortex is an important part of the brain that is responsible for many of our cognitive abilities. The prefrontal cortex is required for our analytical thinking (problem solving), emotional control and intelligence, verbal communication, and memory forming abilities.

The Prefrontal Cortex and Planning

So what would happen if you remove only the prefrontal cortex from the frontal lobe of the brain?

First, let us consider that the prefrontal cortex is interconnected with many areas throughout the brain, including sensory and motor areas[1,2] and posterior association cortices. [3-6]

Note that posterior association area is referring to the area located between the occipital, temporal and parietal lobes. It links information from primary and unimodal sensory areas, and is important in perception and language.

Although the prefrontal cortex is interconnected with many other parts of the brain, damage to the prerfontal cortex does not result in any immediately obvious impairment to cognition and intelligence [7]. But given that the prefrontal cortex is connected to many different parts of the brain, a change should be expected if the prefrontal cortex is damaged.

The first studies of a monkey’s prefrontal cortex didn’t observe significant changes in behavior when removing parts of the prefrontal cortex surface. And again, no substantial behavioral change was observed when the entire left or right prefrontal cortex was surgically removed.

However, it wasn’t until both left and right prefrontal cortices were removed that a drastic change in the monkey’s behavior was observed. The monkeys without any prefrontal cortex left showed something called “disinhibited, stimulus-bound behavior” that lacked goal direction and understanding the context or condition behind an action or event.[8]

In other words,the monkeys would automatically perform simple actions in response to a stimulus, almost like a reflex.

door handleTo illustrate what this means, these monkeys were taught to do a certain action according to a stimuli- before their whole prefrontal cortex was removed. For example, how to open a door by its handle.

After the prefrontal cortex was removed, the monkeys would still reach for a door handle if they saw one.

However, the monkeys without the prefrontal cortex could not open the door- which is a complex, goal-oriented action that requires turning the handle and moving the door to open.

This goes to show that the prefrontal cortex is required for planning and acting according to a plan. The monkeys without the prefrontal cortex could only do an action reflexively without knowing why they are doing it.

Prefrontal Cortex and Self Control

Humans with significant prefrontal impairments from strokes or traumatic-injuries can display similar disinhibited symptoms termed “inappropriate utilization behaviors”.

Certain objects and settings can compel these individuals to perform the associated action without regard to the appropriateness of the context [9,10]. Many fascinating anecdotal stories of these patients with damage to the PFC are available.

For example, one story recounts of a patient who had worked in an executive position for numerous years prior to his frontal stroke. Now he would enter his doctor’s office and unconsciously take a seat behind the desk in the doctor’s chair.

Another patient, upon seeing a stapler, was compelled to staple together any loose paper that was sitting on the desk.

Yet another patient saw a toothbrush and automatically picked it up to brush her teeth. When the doctor asked her why she was brushing her teeth, she simply said she didn’t know.

cerebrum cross section hemisphere showing prefrontal cortex region
By Database Center for Life Science. [CC BY-SA 2.1 jp], via Wikimedia Commons
These anecdotes show that the prefrontal cortex is required for our judgment or our decision making ability. Whether to do something, or not. Without the prefrontal cortex, a person no longer has the ability to say no. Instead, he or she would act habitually according to a stimuli.

That’s why one patient started brushing his teeth for no reason. Because that is the habit that he/she learned; that is the action (brushing) that he or she has learned to associate with that object (brush). Without the prefrontal cortex, the patient loses his ability to decide when or when not to perform an action; when or when not to brush his or her teeth.

And perhaps the prefrontal cortex may hold the answer to why some people have a hard time quitting an addiction. In fact, many studies show that the prefrontal cortex plays a significant role in our ability to control an addiction. “Disruption of the PFC [prefrontal cortex] in addiction underlies not only compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of free will[11].

According to the review, a person with a damaged Prefrontal Cortex is more likely to compulsively take drugs, because we need the prefrontal cortex to function properly for our “free will”. We rely on the prefrontal cortex to overcome our primary instincts, desires, or addictions.

Because the prefrontal cortex is related to our self-control, I speculate that a damage or malfunction to the prefrontal cortex may lead to Obsessive-Compulsive Disorder (OCD), given that the symptoms of OCD fits the fact that a person may perform an action compulsively, reflexively, or without self-control.

Furthermore, it is observed that prefrontal cortex damage also effects our emotional self-control, leading to emotional lability and volatile behaviors.

Where emotional lability refers to patients who experience extreme mood swings that may quickly change from one emotion to another. These patients sometimes express emotions outwardly that aren’t the same as their emotions on the inside.

phineas gage tamping iron through skull imageSo for prefrontal cortex damage, emotional lability and volatile behaviors is specifically seen in orbital frontal lesions, such as the classic story of Phineas Gage. Although Phineas had survived having an iron tamping rod running through his face and the brain’s left frontal lobe, anecdotal stories of him in the following years describe him as impetuous and irritable, as well as socially inappropriate (though in much later years, he eventually relearned much of his lost interpersonal skills).

Prefrontal Cortex and Language Processing

The prefrontal cortex plays a very important role in language.

Specifically, the left inferior prefrontal cortex, especially the anterior and inferior parts of the gyrus, is shown to be associated with semantic mental activities[12]. That means this region of the brain experiences increased energy metabolism (i.e. increased blood flow, increased glucose intake) when a person performs mental operations related to semantics. In other words, the left prefrontal cortex is responsible for mental operations that involve understanding language meanings.

The Prefrontal Cortex and Semantics

semantic relationship between words diagram
A network showing the semantic relationship between words

So the question is, how did scientists learn that the left prefrontal cortex is connected to language processing, specifically semantic functions?

Well, researchers scanned the brain’s of human test subjects while they performed semantic tasks and non-semantic tasks. The researchers compared the differences between the brain scans, and found that the left prefrontal cortex “turned on” or activated, meaning increased in blood flow and glucose intake, during the performance of a semantic task compared to a non-semantic task.

Note that a semantic task entail the generations of words (verbs like “tie”) to a semantic cue (nouns like “shoe”), and the classification of words or pictures into a specific category.

A non-semantic task may be something along the lines of judging whether a word is in upper or lower case (e.g. CHAIR vs. chair), or if the first and last letters of a word is ascending or descending (e.g. car, zone, etc.).

Scientists have also found that people who are atypically right brain hemisphere dominant in language experienced activation in the right prefrontal cortex for semantic tasks.

In other words, semantic functions belong to side of the brain that is dominant for language processing- and is not necessarily bound to one side of the prefrontal cortex. It is just that the norm for many people is to have the left prefrontal cortex to be dominant for semantic language processing.

Another observation that scientists have made is that novel semantic stimuli activates the left prefrontal cortex, leading to better explicit memory formation. That means performing a semantic task forms a memory for the person that can be actively recalled. Note that explicit memory is the type of memory that requires conscious recall, like facts, ideas, meanings, concepts, places, etc.

Repetition Priming and Left Prefrontal Cortex Activation

diagram showing activation of prefrontal cortex
Averaged fMRI activation in the prefrontal cortex over eight subjects for three coronal slice locations (20, 28, and 35 mm anterior to the anterior commissure). (Top) Areas that were more active for semantic processing (abstract/concrete judgment) than for phonological processing (syllable judgment). (Middle) Regions that were more active for phonological processing than for perceptual processing (letter case judgment). (Bottom) Areas that were activated for semantic processing of words compared with phonological processing of pronounceable nonwords. Left inferior frontal cortex (Brodmann areas 45 and 47) is located just above and below the left end of the horizontal line. Activation in left inferior cortex is prominent when semantic judgments are made (Top and Bottom) but not when phonological judgments are made (Middle). John D. E. Gabrieli, Russell A. Poldrack, and John E. Desmond. The role of left prefrontal cortex in language and memory. PNAS 1998 95: 906-913. Copyright (1998) National Academy of Sciences, U.S.A.

However, repeated semantic stimuli (repetition priming) deactivates the prefrontal cortex, leading to the formation of implicit memory. Note that implicit memory is the type of memory that is remembered unconsciously, like tying your shoes or riding a bike.

And it makes sense that the left prefrontal cortex is “deactivated” with repeated semantic stimuli. Because at this point, the brain can simply recall the memory related to that particular semantic stimuli, instead of processing the information through the left prefrontal cortex again. This means that the left prefrontal cortex is not needed as much when recalling a semantic memory, vs processing a novel semantic stimuli that is not known by memory.

To explain it in an example, let’s say that a person is asked whether a word referred to concrete (“table”) or abstract (“truth”) entities. The first time the word, let’s say “pie”, is asked about, the person will take a moment to judge that it is a concrete object. But if the same word is asked about again (repeated semantic stimuli), then the person will give the same answer at a faster speed from memory without needing to re-think the answer.

Summary of the Semantic Role of the Left Prefrontal Cortex

To summarize, the prefrontal cortex is responsible for tasks that require semantic information processing, or the ability to understand the meaning behind language. This also means that the prefrontal cortex is associated with the formation of semantic memories- given that semantic memories are a type of information that is processed or obtained through the prefrontal cortex. The left prefrontal cortex is used for interpreting new meanings from words. However, it is used less for remembering a meaning previously assigned to a word.

And here’s the summary of the PNAS journal article that I used, if you are curious:

It is hypothesized that activations in left inferior prefrontal cortex reflect a domain-specific semantic working memory capacity that is invoked more for semantic than nonsemantic analyses regardless of stimulus modality, more for initial than for repeated semantic analysis of a word or picture, more when a response must be selected from among many than few legitimate alternatives, and that yields superior later explicit memory for experiences.


Taken together, the critical functions of the PFC appear to be related to the processes that help the performance of complex behaviors appropriate for the given context. If a human were to suddenly lose his/her entire PFC, this person would survive, but would also be stimulus-bound.

This person would be unable to plan and execute complex, multi-step actions, and incapable of inhibiting inappropriate extreme behaviors. Plus, this person would no longer be able to verbally express him/herself with language and would have specific memory processing deficits. However, I suspect that word comprehension should be mostly intact (but not grammar), since understanding word meanings relies more on posterior brain regions[13].

Related Links

Related Articles

Books about the Frontal Lobe


  1. Prefrontal connections of medial motor areas in the rhesus monkey [NCBI]
  2. Interconnections between the prefrontal cortex and the premotor areas in the frontal lobe [NCBI]
  3. Diverse thalamic projections to the prefrontal cortex in the rhesus monkey [NCBI]
  4. Prefrontal cortex in relation to other cortical areas in rhesus monkey: architecture and connections [Science Direct]
  5. Functional organization of the human frontal cortex for mnemonic processing [Wiley Online Library]
  6. Frontal lobe connections of the superior temporal sulcus in the rhesus monkey [NCBI]
  7. Frontal cortex and behavior. Annals of neurology [Wiley Online Library]
  8. The mechanism of the brain: and the function of the frontal lobes [Oxford J. Neurol.]
  9. Utilization behaviour and its relation to lesions of the frontal lobes. [NCBI]
  10. The origins of utilization behaviour. [Oxford J. Neurol.]
  11. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications [Nature Reviews Neuroscience]
  12. The role of left prefrontal cortex in language and memory – [PNAS]
  13. Could a human survive without the frontal lobe? [Quora] – A very good read; my article is strongly based off of this professor’s Quora answer.

The Revisionist

I own this blog

2 thoughts to “The Role of the Prefrontal Cortex in our Cognitive Function”

  1. Basically, Frontal cortex is responsible for giving us an illusion of free will. Without this part of our brain humans will do things without giving it a thought. So, what will happen if someone has a larger portion of this part in the brain? I was reading some article about Scott Flansberg (also, dubbed as human calculator) and in that article it was mentioned that Scott Flansberg has a slightly larger prefrontal cortex as compared to other human beings. As a result he has super powers.

    1. Super powers, eh? Who is Scott Flansberg? Is he like the “rain man”?

      So yea, I can guess some people have a better developed prefrontal cortex. And I do believe you can change how well the prefrontal cortex functions, outside of being born with good genes.

      For example, whenever I start lacking motivation or focus, I go out for a run. I exercise. Exercise is an excellent way to improve the function of the prefrontal cortex. I really do feel more intelligent or that it is a lot easier to think and get inspired after a workout. And it makes sense why.

      Exercise improves blood flow to the brain, improves Long Term Potentiation, increases BDNF (brain derived neurotrophic factor), improves the vascular structure in the brain, and improves overall mood:

      Note that BDNF helps support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses in the brain.

What's Your Opinion?