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N-phenylacetyl-L-prolylglycine Ethyl Ester, also known as Noopept, is a touted to be a nootropic that may alleviate cognitive decline.
Noopepet is anxiolytic and mildly psychostimulatory.
It is said that Noopept is 1000 times as potent as Piracetam, although this is a generalization.
Noopept has a molecular structure that is a dipeptide conjugate of Piracetam.
Noopept can be absorbed through the gastrointestinal tract, and is said that it can easily cross the blood brain barrier.
A study has noted that noopept seems to have an anti-amnesiac effect.
Noopept seems to increase Neural Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) concentrations in the hippocampus.
Noopept, in vitro, seems to have a cholinosensitizing effect; I understand that neurons become more sensitive to acetylcholine.
Noopept is observed to help rats overcome the status of learned helplessness.
Noopept seems to cause longer fibril formation of brain neurons.
Noopept itself has a very short half-life.
With noopept, more is usually not better. Most of the time, you will only increase the number of negative side-effects by overdosing on noopept. [Fact check>>>] Rather, it is advised to take 10mg once in the morning, and then 10mg again in the evening.
I personally find that a smaller dose of noopept is more beneficial.
When you use noopept, don’t consider it like every other short-acting drugs that work immediately. There is a nice focus-boosting short-term effect. But Noopept isn’t meant to be used for that. Rather you should use Noopept as a peptide that produces results through hormesis. Although people take Noopept for increasing BDNF in the brain, note that Noopept initially actually decreases BDNF levels in the brain. I believe Noopept acts via hormesis, so my conjecture is that taking more will not improve memory immediately. Quite the opposite actually- ruining your short-term memory and making it impossible to get work done. But again remember, this is the case for overdosing Noopept. With the correct low dosage overtime, BDNF levels should actually be raised in the brain.
Also note that it is recommended to cycle the use of Noopept to prevent downregulation of ___.
It is 10000% about dosage. Play around with your dose and see what works.
I went from the “recommended” 4.8g twice/day of piracetam to 1.2g twice/day and it’s far more powerful with no brain fog.
The fog is caused by too much.
I believe the reason that racetams are so variant is in the differences in people’s diet. I eat lots of turkey and 4+ eggs a day so I’m getting huge amounts of choline. My guess is with such high levels of natural acetylcholine, im prone to being overstimulated when piracetam makes me use more acteylcholine.
I would guess the average persons diet has nearly no choline and thus they need much more piracetam and potentially supplements. [Source] [re-write end]
Does Noopept Require Choline Supplementation?
If you are cholinergically dominant, no.
If you are cholinergically recessive, you’ll do better by stacking your racetams with a cholinergic adjunct. [Source]
How Does Noopept Work?
Noopept enhances the binding activity of Hypoxia Inducible Factor 1 — HIF-1. This is like telling your brain that it doesn’t have enough oxygen and so it has to compensate. At low doses, your brain goes into overdrive to adjust for the “lack” of oxygen, but at higher doses it shuts some operation down to protect against potential death (note, not a danger with noopept, just the mechanism of HIF). Stick to a lower dosage and it’ll work great for you! I’d also recommend tapering off if you take it for an extended period of time; I had shortness of breath for about two months after being on it for three. [Source]
My Thoughts on Noopept
Be careful of using relatively new nootropics. You want to look at not only the studies, but people’s anecdotes about any nootropic, including Noopept. Browsing through forums, it seems that although some people say they benefit from Noopept, others seems to become more suicidal or depressed.
Noopept is an interesting substance. I do believe that it causes neurogenesis in the brain, which parts exactly I have to check. But you have to wonder, how does noopept stimulate neurogenesis in the brain in the first place? Well, I do believe it is by hormesis that noopept acts on the brain; specifically, and I do have to look for studies, noopept causes mild hypoxia or oxygen deprivation upon the cells of the brain. This, I do believe, isnt’ enough to kill the brain cells outright, but enough oxygen deprivation to bring out an adaptive response from the brain. Which is via neurogenesis. I do also believe that oxygen deprivation may also promote the growth of more blood vessels, as an increase in blood delivery may help compensate for low oxygen levels.
This actually explains why too much noopept can have negative side effects like brain fog. So for those who do use noopept as a brain supplement, do please be careful with the dosage that you take. Indeed, you should treat noopept as a mild poison that is may bring out a beneficial adaption in small amounts, but actually become substantially harmful in bigger amounts. The dose makes the poison, after all.
I believe noopept works through hormesis, as it 1st temporarily decreases levels of BDNF in the brain, and then causes the brain to balance by increasing BDNF levels. So the benefit of noopept may be shown overtime or accumulatively. Noopept affects the cholinergic system in the brain, which may explain how it may improve maintained focus.
My Experience with Noopept
So far, my experience with noopept has shown me that the dosage is really a key part.
Initially I have taken 7mg sublingually to see what effect it has on me. I found that my sight was slightly enhaneced, as if I could see slightly farther or it could have been a improved saturation of color. I had a few negative side effects, which include a very mild but persistent headache or head “pressure”. Perhaps this is described by others as brain fog?
The next day I dosed 10mg sublingually, and I noticed an increase in the headache symptom. I could not think clearly, perhaps because of this headache, and I plan to take a smaller dose the next day.
Note that what I mean by sublingual dosage is to measure the noopept powder on a scale, transfer the powder into my mouth and leave it in there for about a minute, preferably under the tongue. I then take some water, swish the mixture in my mouth and swallow. So technically I would have both sublingual and oral administration by this method.
I also noticed that noopept really helps me to focus on my work, even if I don’t want to do it initially. Normally I would procrastinate on it, like if it was filing taxes or something academic. But after taking 5mg of noopept, I suddenly find that pin-point laser focus, and it no longer becomes a matter of self-discipline or motivation to work. I just do it. It’s a great study or productivity aid, I am finding. I remember reading that Noopept affects the cholinergic system in the brain, so this may help explain the positive effect.
Indeed I have to agree with someone who said that Noopept is like taking a dose of Ritalin. But without all the bad side effect from that drug.
I also find that noopept taken right after a workout eliminates any mental fatigue or mental tiredness felt from the work out.
There are 2 key aspects when it comes to noopept. Dosing and effect over time. I find that the less of a dose of noopept you take, the more beneficial it is. With higher doses, you run into increased side effects like brain fog and headaches. Some people even permanently “damaged” their brain by taking higher doses. Remember, Noopept is more or less a research chemical, not a vitamin or traditional stimulant. More is not better. Less is.
Moreso the case given that I’ve heard that Noopept has a reverse tolerance. So smaller doses should theoretically yield a bigger effect overtime.
Another thing you should keep in mind is whether your scale measures single miligrams accurately. If not, you may end up taking twice or thrice the amount of Noopept you originally intended too! And the dosage controls how it affects you, and how many side affects you get.
A good trick to make some miligram scales more accurate is to make sure nothing is on the scale, that means removing the weighing pan 1st. Turn on the scale, set the weigh pan. Tare it, and then measure out the amount of noopept powder you want to dose. I find that for my scale, this helps with accuracy, but not all cheap miligram scales are the same, so it depends on a case-by-case basis.
Noopept & Lion’s Maine Combo
I am also finding right now that Noopept in combination with Lion’s Maine after exercise is an extremely good combination. I’m not sure of taking Noopept and Lion’s Maine long-term, but for the 1st time I tried it I find that I have extreme focus, productivity, and heightened cognition overall. I find that article writing suddenly becomes a lot easier, and maintain longer sessions of work. Although Noopept is a medicine that targets to increase BDNF, initially it actually decreases levels of BDNF in the brain. It reminds of how low doses of poisons were used as medicines to induce a hormetic effect. Likewise, Noopept causes the brain to adapt to lower levels of BDNF, making the brain produce more BDNF overtime to compensate.
So my theory is that Lion’s Maine makes up for the BDNF deficit caused by the Noopept. Theoretically, Lion’s Maine would therefore reduce the brain fog side effect caused by Noopept, which I believe is caused by lower BDNF levels.
The next aspect to this dual stack is that Noopept affects the cholinergic system in the brain, which causes the improved focus. Noopept all by itself would give you focus, but brain fog with higher doses. I don’t believe supplementing with acetylcholine would help here, because the deficit is from a lack of BDNF. That’s why it seems like Lion’s Maine works in my case.
Noopept has a great productivity enhancing short-term effect. But to acquire this benefit, it is a little tricky. Just taking noopept orally is not enough. Rather, I found that I get a lot of benefit from Noopept short-term when I take it sublingually. And I found that the longer you can keep the noopept powder in contact with the “oral mucosa” or inside membrane of the mouth, the more pronounced the short-term benefits appear to me. And I find that the short-term benefits are non-existent, unobservable, or lost when taken orally or when the powder is not allowed enough time or contact during sublingual administration.
To properly administer noopept sublingually, you have to ensure long contact time under the tongue, and swish the rest of the powder with water in the mouth for a bit to maximize contact area and sublingual absorption.
When I nail down the sublingual administration of noopept, I find that immediate short-term benefits that scale according to how well the noopept absorbed through the oral mucosa. There is an immediate lift in depression, brain fog, executive function, and an immediate urge to start doing something productive. It becomes a lot easier to absorb and output information as well.
In my experience, I don’t typically get brain fog from noopept, if at all. But I do find that it won’t substitute for a good night of sleep. If you are sleep deprived, it won’t really make you feel less tired mentally. And on the same vein, I personally found that it should not be taken before going to sleep. Perhaps because of its neurostimulating qualities from activating the BDNF production and the glutamate system, I find that taking noopept before sleep lowers my quality of sleep, and although I sleep more to compensate, I don’t really get the deep sleep that I need to feel refreshed. So perhaps don’t take it before going to sleep.
Another side-effect that I experienced is that noopept affects my GI tract. I personally have a sensitive stomach, so I found that taking noopept orally gives me a laxative effect. For this reason I changed my administration method from oral to nasal administration.
There are several reasons where it is suggested not to use noopept. For example, if you have:
- Cardiovascular issues
- Autoimmune disorders
You may have to avoid using noopept if you have cardiovascular issues because noopept increases blood pressure.
Bad User Experience Reports
A user with a history of benzo (xanax), alcohol, ritalin, marijuana usage claims excitotoxicity from noopept dosage of 50mg after 25mg daily. [LongeCity]
Good User Experience Reports
Enhanced perception, enhanced vision, smell, hearing, focus. Improved spatial memory, improvements in social interaction. Lingering cognitive benefits after withdrawal. Reduced Anxiety. Increased Motivation. But negative side effect reports is irritability. A different user on the same thread reported depression and suicidal sentiments after withdrawing from a high dosage [LongeCity].